Nampt-IN-16
Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC50 of 0.15 μM. Nampt-IN-16 can reduce intracellular NAD+ and ATP levels. Nampt-IN-16 can inhibit the proliferation, migration, and invasion, induce cell cycle arrest and apoptosis, and alter cellular metabolism of gastric cancer cells. Nampt-IN-16 can be used in the research of tumors such as gastric cancer[1].
Product Specifications
CAS Number
[3077970-44-3]
UNSPSC
12352005
Target
Apoptosis; NAMPT
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(CNC(C2=C(N3CCCC3)C=CC(F)=C2)=O)C=C1)OCC4=CC=CN=C4
Molecular Formula
C25H25FN4O3
Molecular Weight
448.49
References & Citations
[1]Zhang S, et al. Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis. J Med Chem. 2025 Jun 12;68 (11) :10738-10756.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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