PDE5-IN-14

PDE5-IN-14 (Compound 14a) is a brain-penetrant competitive phosphodiesterase 5 (PDE5) inhibitor (IC50=16.11 nM) . PDE5-IN-14 is promising for research of Alzheimer’s disease (AD), cancer and cardiovascular diseases[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

O=C(C1=CN(CCN(C)C)C2=C1C=C(C#N)C=C2)NCC3=CC=C(OC)C(Cl)=C3

Molecular Formula

C22H23ClN4O2

Molecular Weight

410.90

References & Citations

[1]Park SY, et al. Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation. ACS Med Chem Lett. 2025 May 28;16 (6) :1058-1065.