PDE5-IN-14
PDE5-IN-14 (Compound 14a) is a brain-penetrant competitive phosphodiesterase 5 (PDE5) inhibitor (IC50=16.11 nM) . PDE5-IN-14 is promising for research of Alzheimer’s disease (AD), cancer and cardiovascular diseases[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(C1=CN(CCN(C)C)C2=C1C=C(C#N)C=C2)NCC3=CC=C(OC)C(Cl)=C3
Molecular Formula
C22H23ClN4O2
Molecular Weight
410.90
References & Citations
[1]Park SY, et al. Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation. ACS Med Chem Lett. 2025 May 28;16 (6) :1058-1065.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-176235/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5
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