DNMT-IN-5

DNMT-IN-5 is a stable and efficient DNA methyltransferase (DNMT) inhibitor with high stability and high activity with an IC50 of 0.78 nM. DNMT-IN-5 exhibits sub-micromolar DNMT3A inhibitory activity, upregulates the expression of DNMT-targeted genes, impairs cell proliferation, and triggers a critical cell cycle arrest. DNMT-IN-5 can be used for the study of p53-depleted colorectal cancer[1].

Product Specifications

UNSPSC

12352005

Target

DNA Methyltransferase

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C(Cl)(C(OC)(OC2=CC=CC=C21)C3=CC=CC=C3)Br

Molecular Formula

C16H12BrClO3

Molecular Weight

367.62

References & Citations

[1]1. Calzaferri F et al. Rational Design and Synthesis of Highly Stable Haloflavanone DNA Methyltransferase Inhibitors Inducing Tumor Suppressor Gene Re-expression in Cancer Cells. J Med Chem. 2025 Jun 12;68 (11) :10704-10721. doi: 10.1021.