DNMT-IN-5
DNMT-IN-5 is a stable and efficient DNA methyltransferase (DNMT) inhibitor with high stability and high activity with an IC50 of 0.78 nM. DNMT-IN-5 exhibits sub-micromolar DNMT3A inhibitory activity, upregulates the expression of DNMT-targeted genes, impairs cell proliferation, and triggers a critical cell cycle arrest. DNMT-IN-5 can be used for the study of p53-depleted colorectal cancer[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C(Cl)(C(OC)(OC2=CC=CC=C21)C3=CC=CC=C3)Br
Molecular Formula
C16H12BrClO3
Molecular Weight
367.62
References & Citations
[1]1. Calzaferri F et al. Rational Design and Synthesis of Highly Stable Haloflavanone DNA Methyltransferase Inhibitors Inducing Tumor Suppressor Gene Re-expression in Cancer Cells. J Med Chem. 2025 Jun 12;68 (11) :10704-10721. doi: 10.1021.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT3
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