Mpro/Cathepsin L-IN-2
Mpro/Cathepsin L-IN-2 (Compound 1) is a dual irreversible inhibitor of SARS-CoV-2 main protease (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64) . Mpro/Cathepsin L-IN-2 is promising for research of COVID-19 and other coronavirus infections[1].
Product Specifications
UNSPSC
12352211
Target
Cathepsin; SARS-CoV; Virus Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=CC=CC2=C1C=C(C(N[C@@H](CC3=CC(F)=CC=C3)C(N[C@H](C(COC4=C(F)C(F)=C(CO)C(F)=C4F)=O)C[C@@H]5CCNC5=O)=O)=O)N2
Molecular Formula
C34H31F5N4O7
Molecular Weight
702.62
References & Citations
[1]Porzberg MRB, et al. Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 Mpro and Cathepsin. J Med Chem. 2025 Jun 12;68 (11) :10953-10969.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin L
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
