Mpro/Cathepsin L-IN-2

Mpro/Cathepsin L-IN-2 (Compound 1) is a dual irreversible inhibitor of SARS-CoV-2 main protease (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64) . Mpro/Cathepsin L-IN-2 is promising for research of COVID-19 and other coronavirus infections[1].

Product Specifications

UNSPSC

12352211

Target

Cathepsin; SARS-CoV; Virus Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

COC1=CC=CC2=C1C=C(C(N[C@@H](CC3=CC(F)=CC=C3)C(N[C@H](C(COC4=C(F)C(F)=C(CO)C(F)=C4F)=O)C[C@@H]5CCNC5=O)=O)=O)N2

Molecular Formula

C34H31F5N4O7

Molecular Weight

702.62

References & Citations

[1]Porzberg MRB, et al. Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 Mpro and Cathepsin. J Med Chem. 2025 Jun 12;68 (11) :10953-10969.