Thalidomide-piperidine-azetidine-Br
Thalidomide-piperidine-azetidine-Br is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based CRBN ligand (HY-41547) and linker (HY-176226) . Thalidomide-piperidine-azetidine-Br can be used for synthesis of BY13 (HY-176225) [1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=C(C=CC=C3N4CCC(N5CC(Br)C5)CC4)C1=O
Molecular Formula
C21H23BrN4O4
Molecular Weight
475.34
References & Citations
[1]Liang J, et al. Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer. J Med Chem. 2025 Jun 12; 68 (11) :11516-11542.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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