IRF1 antagonist 1
IRF1 antagonist 1 (8003-3282) is a potent IRF1 (interferon regulatory factor) antagonist with anti-inflammatory activity. IRF1 antagonist 1 can maintain blood-brain barrier integrity and reduce brain edema. IRF1 antagonist 1 can improve neurological outcomes in an acute traumatic brain injury (TBI) mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Caspase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N/N=C/C1=CC(Br)=CC=C1O)=O)N[C@@H](C)C2=CC=CC=C2
Molecular Formula
C17H16BrN3O3
Molecular Weight
390.23
References & Citations
[1]Cui W, et al. Interferon regulatory factor-1-expressing astrocytes are epigenetically controlled and exacerbate TBI-associated pathology in mice. Sci Transl Med. 2025 May 28;17 (800) :eadr5300.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR10390380 96 Well
Goat Anti-Glutamic Acid Decarboxylase 65 antibody
Sign In for Pricing
View Details 
GTR10414400 96 Well
Mouse Calcium binding mitochondrial carrier protein Aralar2 (SLC25A13) ELISA kit
Sign In for Pricing
View Details 