IRF1 antagonist 1
IRF1 antagonist 1 (8003-3282) is a potent IRF1 (interferon regulatory factor) antagonist with anti-inflammatory activity. IRF1 antagonist 1 can maintain blood-brain barrier integrity and reduce brain edema. IRF1 antagonist 1 can improve neurological outcomes in an acute traumatic brain injury (TBI) mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Caspase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N/N=C/C1=CC(Br)=CC=C1O)=O)N[C@@H](C)C2=CC=CC=C2
Molecular Formula
C17H16BrN3O3
Molecular Weight
390.23
References & Citations
[1]Cui W, et al. Interferon regulatory factor-1-expressing astrocytes are epigenetically controlled and exacerbate TBI-associated pathology in mice. Sci Transl Med. 2025 May 28;17 (800) :eadr5300.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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