α-Glucosidase-IN-92

α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase (IC50=64.0 μM), with better inhibitory potency than Acarbose (HY-B0089) (IC50=750 μM) . α-Glucosidase-IN-92 has good oral bioavailability and can cross the blood-brain barrier. α-Glucosidase-IN-92 can delay carbohydrate hydrolysis and reduce postprandial blood glucose. α-Glucosidase-IN-92 can be used in anti-glycemic research for type 2 diabetes[1].

Product Specifications

UNSPSC

12352005

Target

Glycosidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(C1=CC2=C(C(C3=CC=CC=C3)=N1)NC4=C2C=CC=C4)NCC5=CN(CC(NC6=CC=CC=C6C)=O)N=N5

Molecular Formula

C30H25N7O2

Molecular Weight

515.57

References & Citations

[1]Safaie E, et al. 1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors. Sci Rep. 2025 May 20;15 (1) :17418.