DA-NHbenzylOCF3

DA-NHbenzylOCF3 is a DNA-targeted radiosensitizer that enhances the sensitivity of tumor cells to X-rays through the dissociative electron attachment (DEA) mechanism. dA-NHbenzylOCF3 has low toxicity to normal cells and is mainly localized in the cytoplasm and nucleus after entering the cell. dA-NHbenzylOCF3 exerts radiosensitization effects by inducing cell cycle arrest in the radiosensitive G2/M phase. dA-NHbenzylOCF3 can be used for radiosensitization studies of malignant tumors such as prostate cancer and breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Biochemical Assay Reagents; DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Purity

98.04

Smiles

O[C@H]1C[C@@H](O[C@@H]1CO)N2C(NCC3=CC=C(OC(F)(F)F)C=C3)=NC4=C(N=CN=C42)N

Molecular Formula

C18H19F3N6O4

Molecular Weight

440.38

References & Citations

[1]Datta M, et al. Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties. Sci Rep. 2025 May 20;15 (1) :17535.