JNK2/3-IN-1
JNK2/3-IN-1 (Compound 56d) is an irreversible covalent inhibitor of c-Jun N-terminal kinases 2/3 (JNK2/3) with IC50 values of 830 and 1909 nM, respectively. JNK2/3-IN-1 is promising for research of neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s) and fibrotic disorders[1].
Product Specifications
UNSPSC
12352005
Target
JNK
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=CC(N2N=CC(NC(NC3=C4C=CC=CC4=CC=C3)=O)=C2)=C1)C5=CC=CC(NC(C=C)=O)=C5
Molecular Formula
C30H24N6O3
Molecular Weight
516.55
References & Citations
[1]Wydra VR, et al. A "Ligand First" Approach toward Selective, Covalent JNK2/3 Inhibitors. J Med Chem. 2025 Jun 12;68 (11) :12004-12028.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK2; JNK3
Curated Selection
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