Ferroptosis-IN-20

Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC50: 24.2 nM) targeting voltage-dependent anion channel (VDAC) . Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe2+ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637) -induced acute kidney injury (AKI) [1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis; Reactive Oxygen Species (ROS) ; VDAC

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

COC1=C(C=C(C2=C1CN3C(C4=CC5=C(C=C4CC3)OCO5)C2)NC6=CC=CC(C7=CC=C(C=C7)F)=C6)OC

Molecular Formula

C32H29FN2O4

Molecular Weight

524.58

References & Citations

[1]Peng S, et al. Discovery of THB Derivates as Ferroptosis Inhibitors for the Treatment of Acute Kidney Injury by Targeting VDAC. J Med Chem. 2025 Jun 12;68 (11) :11340-11364.