Ferroptosis-IN-20
Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC50: 24.2 nM) targeting voltage-dependent anion channel (VDAC) . Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe2+ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637) -induced acute kidney injury (AKI) [1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; Reactive Oxygen Species (ROS) ; VDAC
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=C(C=C(C2=C1CN3C(C4=CC5=C(C=C4CC3)OCO5)C2)NC6=CC=CC(C7=CC=C(C=C7)F)=C6)OC
Molecular Formula
C32H29FN2O4
Molecular Weight
524.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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