CYP51-IN-24
CYP51-IN-24 (Compound 22) is a Sterol 14α-Demethylase (CYP51) inhibitor. CYP51-IN-24 exhibits potent inhibitory activity against wild-type and drug-resistant fungi. CYP51-IN-24 inhibits ergosterol biosynthesis by binding to the fungal CYP51 enzyme. CYP51-IN-24 can be used in research and drug development against drug-resistant fungal infections[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; Fungal
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
FC1=C(C=CC(F)=C1)C(O)(CNC(C2=CC=C(C=C2)C3=CC=C(C=C3)OC(F)(F)F)=O)CN4C=NC=N4
Molecular Formula
C25H19F5N4O3
Molecular Weight
518.44
References & Citations
[1]Alsulaimany M, et al. Exploring Long Arm Amide-Linked Side Chains in the Design of Antifungal Azole Inhibitors of Sterol 14α-Demethylase (CYP51) . J Med Chem. 2025 Jun 12;68 (11) :10781-10799.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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