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HDAC degrader-1

HDAC6 degrader-6 (compound 10c) is a ByeTAC protein degrader targeting HDAC6, with IC50 values of 0.034 μM, 0.166 μM, 0.703 μM, and 0.293 μM for HDAC6, HDAC1, HDAC2, and HDAC3, respectively. HDAC6 degrader-6 induces cell apoptosis and can be used for the study of multiple myeloma (Blue: USP14 ligand HY-159808; Pink: HDAC ligand HY-176209; Black: linker HY-W016871)

Product Specifications

UNSPSC

12352211

Target

ByeTAC; HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(CC(NCCCCCCCCCCNC(C2CN(CC(C3=C(C)N(C4=CC=C(F)C=C4)C(C)=C3)=O)CC2)=O)=O)C=C1)CCCCCCC(NO)=O

Molecular Formula

C45H63FN6O6

Molecular Weight

803.02

References & Citations

[1]Sun T, et al. Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs) . ACS Med Chem Lett. 2025 May 20;16 (6) :1155-1162.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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