HDAC degrader-1
HDAC6 degrader-6 (compound 10c) is a ByeTAC protein degrader targeting HDAC6, with IC50 values of 0.034 μM, 0.166 μM, 0.703 μM, and 0.293 μM for HDAC6, HDAC1, HDAC2, and HDAC3, respectively. HDAC6 degrader-6 induces cell apoptosis and can be used for the study of multiple myeloma (Blue: USP14 ligand HY-159808; Pink: HDAC ligand HY-176209; Black: linker HY-W016871) [1]
Product Specifications
UNSPSC
12352211
Target
ByeTAC; HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(CC(NCCCCCCCCCCNC(C2CN(CC(C3=C(C)N(C4=CC=C(F)C=C4)C(C)=C3)=O)CC2)=O)=O)C=C1)CCCCCCC(NO)=O
Molecular Formula
C45H63FN6O6
Molecular Weight
803.02
References & Citations
[1]Sun T, et al. Targeted Degradation of Histone Deacetylases via Bypassing E3 Ligase Targeting Chimeras (BYETACs) . ACS Med Chem Lett. 2025 May 20;16 (6) :1155-1162.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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