Axl-IN-19
Axl-IN-19 (Compound 68) is a selective AXL (a membrane-bound receptor tyrosine kinase) inhibitor (IC50: 5.3 nM; Cellular KD = 6.8 nM) . Axl-IN-19 has favorable rat PK with low clearance and moderate bioavailability. Axl-IN-19 can be used for cancer research[1].
Product Specifications
CAS Number
[2870696-46-9]
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN(C(C1=CC=C(C=C1)C2=NNC3=NC=C(C=C32)C4=CC=C5CC[C@@H](CCC5=C4)N6C7COCC6C7)=O)C
Molecular Formula
C31H33N5O2
Molecular Weight
507.63
References & Citations
[1]Foley CN, et al. Discovery and Characterization of Potent, Selective, and Orally Bioavailable 7-Azaindazole AXL Receptor Tyrosine Kinase Inhibitors. J Med Chem. 2025 May 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl
Curated Selection
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