TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC

TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC (compound LIV1-IMC (12) linker-payload) is a linker-payload conjugate, used in the synthesis of antibody-drug conjugates (ADCs) .TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC contains TLR7/8 agonist (HY-170770) (ADC payload) and a linker (HY-176478) [1].

Product Specifications

CAS Number

[3080930-77-1]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCC[C@H](NC1=NC(N)=NC2=C1N(C3=C2C=CC=C3)CC4=C(C=CC(CN(C(OCC5=C(C(NCCOCCOCCOCCOC)=O)C=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)C=C5)=O)[C@H]7CCOC7)=C4)OC)CCO

Molecular Formula

C72H102N14O19

Molecular Weight

1467.66

References & Citations

[1]Yamazoe S, et al. Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity. J Med Chem. 2025 May 24.