TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC
TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC (compound LIV1-IMC (12) linker-payload) is a linker-payload conjugate, used in the synthesis of antibody-drug conjugates (ADCs).TLR7/8 agonist 12-PAB- (PEG4-Me) -Cit-Val-PEG2-amide-C2-MC contains TLR7/8 agonist (ADC payload) and a linker (HY-176478).
Product Specifications
CAS Number
3080930-77-1
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCC[C@H](NC1=NC(N)=NC2=C1N(C3=C2C=CC=C3)CC4=C(C=CC(CN(C(OCC5=C(C(NCCOCCOCCOCCOC)=O)C=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)C=C5)=O)[C@H]7CCOC7)=C4)OC)CCO
Molecular Formula
C72H102N14O19
Molecular Weight
1467.66
References & Citations
[1]Yamazoe S, et al. Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity. J Med Chem. 2025 May 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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