P-gp modulator-7

P-gp modulator-7 (Compound 9e) is a P-glycoprotein (P-gp) inhibitor. P-gp modulator-7 occupies the channel entrance of P-gp with a unique T-shaped configuration, hindering the peristaltic extrusion mechanism of transmembrane domains TM12 and TM9, thereby inhibiting P-gp from pumping drugs out of cells and reversing the multidrug resistance (MDR) of tumor cells. P-gp modulator-7 is promising for research of cancers[1].

Product Specifications

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

O=C(O[C@@H]1C[C@@]2([C@]3(CCC(C(C)([C@]3([H])CC[C@]2([C@@]4(CC[C@]([C@]5(C)CC[C@H](O5)C(C)(O)C)([C@@]14[H])[H])C)C)C)=O)C)[H])CN6CCNCC6

Molecular Formula

C36H60N2O5

Molecular Weight

600.87

References & Citations

[1]Chen C, et al. Design, synthesis, and biological evaluation of C-12 modified ocotillol-type derivatives as novel P-glycoprotein modulators for overcoming multidrug resistance. Eur J Med Chem. 2025 Sep 15;294:117757.