SMU-14a
SMU-14a is a TLR3 inhibitor (IC50: 0.18 µM) . SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-α in human peripheral blood monocytes. SMU-14a exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 through NF-κB, MAPK, and IRF3 signaling pathways, and decreasing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. SMU-14a can be used in the study of acute hepatitis[1].
Product Specifications
UNSPSC
12352005
Target
ERK; IKK; NF-κB; p38 MAPK; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1)NC5=CC=CC=C5N
Molecular Formula
C24H20N4O
Molecular Weight
380.44
References & Citations
[1]Cao Z, et al. Ellipticine derivatives as Toll-like receptor 3 inhibitor for treating acute hepatitis. Eur J Med Chem. 2025 Sep 15;294:117762.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-176192/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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