Thalidomide-4-PEG4-OTs
Thalidomide-4-OH-PEG4-OTs is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based CRBN ligand (HY-103596) and 4-unit PEG linker (HY-176182) . Thalidomide-4-OH-PEG4-OTs can be used for synthesis of PROTAC STING degrader-4 (HY-176180) [1].
Product Specifications
CAS Number
[3023389-80-9]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=C(OCCOCCOCCOCCOS(C4=CC=C(C=C4)C)(=O)=O)C=CC=C3C1=O
Molecular Formula
C28H32N2O11S
Molecular Weight
604.63
References & Citations
[1]An Y, et al. Discovery of indole derivatives as STING degraders. Eur J Med Chem. 2025 May 12; 294:117747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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