PROTAC STING degrader-4
PROTAC STING degrader-4 is a nitro-free covalent STING PROTAC degrader with a DC50 of 3.23 μM. PROTAC STING degrader-4 effectively inhibits STING as well as its downstream signaling, such as p-TBK1 and p-NF-κB (p-P65), and immune-inflammatory cytokines. PROTAC STING degrader-4 mitigates kidney and blood inflammation in Cisplatin (HY-17394) -induced acute kidney injury (AKI) mice model[1]. Pink: STING ligand (HY-176183) ; Blue: CRBN ligase ligand (HY-103596) ; Black: linker (HY-176182) ; CRBN ligase ligand + linker: HY-176181
Product Specifications
UNSPSC
12352005
Target
IKK; NF-κB; PROTACs; STING
Related Pathways
Immunology/Inflammation; NF-κB; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
ClC(C=C(C=N1)NC(NC2=CNC3=CC=C(C=C32)Cl)=O)=C1N(CC4)CCN4CCOCCOCCOCCOC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O
Molecular Formula
C39H42Cl2N8O9
Molecular Weight
837.70
References & Citations
[1]An Y, et al. Discovery of indole derivatives as STING degraders. Eur J Med Chem. 2025 May 12; 294:117747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB; TBK1
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