CDK2-IN-46
CDK2-IN-46 (compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.3 nM. CDK2-IN-46 has a selectivity of >200-fold for CDK1, CDK7, CDK9, CDK4, and CDK6. CDK2-IN-46 shows improves rat and cyno pharmacokinetic profiles[1].
Product Specifications
CAS Number
[2498658-21-0]
UNSPSC
12352005
Target
CDK; Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC([2H])([2H])[2H])(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O
Molecular Formula
C21H22D3N5O4S
Molecular Weight
446.54
References & Citations
[1]Sokolsky A, et al. Discovery of 5,7-Dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors. ACS Med Chem Lett. 2022 Oct 6;13 (11) :1797-1804.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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