SOS1-IN-19

SOS1-IN-19 (Compound 10i) is a potent inhibitor of SOS1 (Son of Sevenless 1) with an IC50 value of 165.2 nM. SOS1-IN-19 blocks KRAS activation by preventing GDP/GTP exchange in KRAS signaling pathway. SOS1-IN-19 is promising for research of KRAS-driven cancers (e.g., NSCLC and colorectal cancer) [1].

Product Specifications

UNSPSC

12352005

Target

SOS1

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Smiles

COC1=C(OC)C=C2C(N=C(N3CC(N(C)C)C3)N=C2N[C@H](C)C4=CC(N)=CC(C(F)(F)F)=C4)=C1

Molecular Formula

C24H29F3N6O2

Molecular Weight

490.52

References & Citations

[1]Chen Y, et al. Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130282.