PD-M6

PD-M6 is an mTOR PROTAC degrader (DC50: 4.8 μM) . PD-M6 promotes the ubiquitination and degradation of mTOR. PD-M6 inhibits the proliferation of HeLa, MCF-7, and HepG2 cancer cell lines (IC50 values of 11.3, 2.58, and 3.23 μM, respectively) and induces autophagy. PD-M6 specifically induces the degradation of LAMTOR1, a key protein in the mTOR signaling pathway. (Pink: target protein mTOR ligand (HY-B0795) ; target protein mTOR ligand activity control (HY-W150930) ; black: linker (HY-W008296) ; blue: E3 ligase CRBN ligand (HY-41547) ; target protein ligand activity control + linker (HY-176167) ) [1].