CDK9/EZH2-IN-1
CDK9/EZH2-IN-1 (Compound D16) is a CDK9/EZH2 dual-target inhibitor (IC50: 83.9/108.6 nM) . CDK9/EZH2-IN-1 induces apoptosis and DNA double-strand breaks (DSBs) . CDK9/EZH2-IN-1 inhibits the proliferation activity of MKN45, MDA-MB-453 and SW620 cancer cells (IC50 values are 136.3, 171.3 and 315.7 nM, respectively) [1].
Product Specifications
CAS Number
3081246-18-3
UNSPSC
12352005
Target
CDK; Histone Methyltransferase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
97.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C)=C(C(N1)=O)CNC(C2=CC(C3=CC=C(N=C3)N4CCN(CC4)CCN5CCC(CC5)C(NC6=NC=C(S6)SCC7=NC=C(O7)C(C)(C)C)=O)=CC8=C2C=NN8C(C)C)=O
Molecular Formula
C47H59N11O4S2
Molecular Weight
906.17
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; EZH2
Frequently Asked Questions
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