CDK9/EZH2-IN-1

CDK9/EZH2-IN-1 (Compound D16) is a CDK9/EZH2 dual-target inhibitor (IC50: 83.9/108.6 nM) . CDK9/EZH2-IN-1 induces apoptosis and DNA double-strand breaks (DSBs) . CDK9/EZH2-IN-1 inhibits the proliferation activity of MKN45, MDA-MB-453 and SW620 cancer cells (IC50 values are 136.3, 171.3 and 315.7 nM, respectively) [1].

Product Specifications

CAS Number

[3081246-18-3]

UNSPSC

12352005

Target

CDK; Histone Methyltransferase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

97.03

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC(C)=C(C(N1)=O)CNC(C2=CC(C3=CC=C(N=C3)N4CCN(CC4)CCN5CCC(CC5)C(NC6=NC=C(S6)SCC7=NC=C(O7)C(C)(C)C)=O)=CC8=C2C=NN8C(C)C)=O

Molecular Formula

C47H59N11O4S2

Molecular Weight

906.17

References & Citations

[1]Tian L, et al. Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects. Eur J Med Chem. 2025 May 17;294:117773.