BJ-13
BJ-13 is a reactive oxygen species (ROS) inducer that can lead to mitochondrial membrane potential collapse and caspase-dependent apoptosis. BJ-13 inhibits the proliferation of SGC-7901, U-87MG, and HepG-2 cancer cells (IC50 values of 15.33, 27.18, and 20.44 nM, respectively) . BJ-13 can be used in the study of gastric cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N(CC1=CC=C(OC)C=C1)C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=C(C(NNC(C4=CC=C(OC)C=C4)=O)=O)C=C3
Molecular Formula
C33H33N3O8
Molecular Weight
599.63
References & Citations
[1]Zhang J, et al. Design, synthesis and biological evaluation of novel 4- (pyrrolo[2,3-d]pyrimidine-4-yloxy) benzamide derivatives as potential antitumor agents. Bioorg Med Chem Lett. 2021 Feb 1;33:127740.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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