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P2Y1/P2Y6 antagonist 1

P2Y1/P2Y6 antagonist 1 (Compound 3h) is an indolesulfonylhydrazide derivative. P2Y1/P2Y6 antagonist 1 is an orally active tP2Y1 and rP2Y6 antagonist (IC50 of 9.72 and 1.89 μM, respectively) . P2Y1/P2Y6 antagonist 1 can be used in the study of neurological diseases, inflammation, cardiovascular diseases and cancer[1].

Product Specifications

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Smiles

O=S(C1=CC=C(OC(F)(F)F)C=C1)(NNC(CC2=CNC3=C2C=CC=C3)=O)=O

Molecular Formula

C17H14F3N3O4S

Molecular Weight

413.37

References & Citations

[1]Hameed A, et al. Synthesis, structure activity relationship and biological evaluation of indole sulfonohydrazide derivatives as antagonists of P2Y1 and P2Y6 receptors. Bioorg Chem. 2025 Jun 15;160:108499.0403644/

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y1 Receptor; P2Y6 Receptor

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