YX0798
YX0798 is a selective and orally active CDK9 inhibitor (Kd: 0.28 nM) . YX0798 downregulates the oncoprotein c-MYC and pro-survival protein MCL-1. YX0798 disrupts the cell cycle and results in transcriptomic reprogramming, eventually leading to cell apoptosis. YX0798 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; CDK; c-Myc
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C([C@H]1CCC[C@H](C1)NC(C(F)(F)F)=O)NC2=NC=C(C(C3=CC=NC4=C3C=CN4)=C2)Cl
Molecular Formula
C21H19ClF3N5O2
Molecular Weight
465.86
References & Citations
[1]Vivian Jiang, et al. YX0798 Is a Highly Potent, Selective, and Orally Effective CDK9 Inhibitor for Treating Aggressive Lymphoma. bioRxiv 2024.12.31.629756
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; Mcl-1
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