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ZH8965

ZH8965 is an orally active TAAR1-Gs/Gq agonist (EC50: 6.1/14.8 nM) . ZH8965 improves antipsychotic-like phenotypes and cognitive impairment in the MK-801-induced mouse psychosis model. ZH8965 can be used in schizophrenia research[1].

Product Specifications

UNSPSC

12352005

Target

Trace Amine-associated Receptor (TAAR)

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Concentration

10mM

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(NC[C@@H]1CCCN1)(C2=CC=CC(OC)=C2)=O.Cl

Molecular Formula

C12H19ClN2O3S

Molecular Weight

306.81

References & Citations

[1]Zhou Z, et al. In Silico Discovery of Novel Potent Trace Amine-Associated Receptor TAAR1 Agonists as Promising Drug Candidates for the Treatment of Schizophrenia. J Med Chem. 2025 May 22;68 (10) :10255-10267.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TAAR1

Available Sizes

Frequently Asked Questions

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