E3 Ligase Ligand-linker Conjugate 185

E3 Ligase Ligand-linker Conjugate 185 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 185 can be used to synthesize RP03707 (HY-176134) [1].

Product Specifications

CAS Number

[3030500-92-3]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(C4CCN(C5CC6(CCNCC6)C5)CC4)=C3)=O

Molecular Formula

C25H33FN6O2

Molecular Weight

468.57

References & Citations

[1]Ji X, et al. Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC. J Med Chem. 2025 May 22;68 (10) :10238-10254.