HNF4 agonist 1
HNF4 agonist 1 (compound 46) is a potent HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC50s of 6 and 17 nM, respectively. HNF4 agonist 1 can be used in the study of maturity-onset diabetes of the young 1 (MODY-1) [1].
Product Specifications
UNSPSC
12352005
Target
Orphan Nuclear Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.37
Smiles
OC(C1=C(C=CC(C#CC2=C(C=C(C=C2)C)Cl)=C1)O)=O
Molecular Formula
C16H11ClO3
Molecular Weight
286.71
References & Citations
[1]Schallmayer E, et al. A First-in-Class Hepatocyte Nuclear Factor 4 Agonist. J Med Chem. 2025 May 8.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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