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HNF4 agonist 1

HNF4 agonist 1 (compound 46) is a potent HNF4 agonist. HNF4 agonist 1 activates HNF4α and HNF4γ with EC50s of 6 and 17 nM, respectively. HNF4 agonist 1 can be used in the study of maturity-onset diabetes of the young 1 (MODY-1) [1].

Product Specifications

UNSPSC

12352005

Target

Orphan Nuclear Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.37

Smiles

OC(C1=C(C=CC(C#CC2=C(C=C(C=C2)C)Cl)=C1)O)=O

Molecular Formula

C16H11ClO3

Molecular Weight

286.71

References & Citations

[1]Schallmayer E, et al. A First-in-Class Hepatocyte Nuclear Factor 4 Agonist. J Med Chem. 2025 May 8.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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