AMX5160

AMX5160 (36) is an orally active BTK inhibitor, with an IC50 of 0.98 nM against mutant BTKC481S. AMX5160 (36) can be used in the research for leukemia, lymphoma, multiple sclerosis, and other autoimmune diseases[1].

Product Specifications

CAS Number

2639293-95-9

UNSPSC

12352005

Target

Btk

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

ClC1=CC(OC2=CC=CC=C2)=CC=C1C(C3=CNC4=NC=CC(N[C@H](CC5)CC[C@H]5NC(C)=O)=C34)=O

Molecular Formula

C28H27ClN4O3

Molecular Weight

502.99

References & Citations

[1]Debasis Das, et al. Discovery of Reversible, Noncovalent Bruton’s Tyrosine Kinase Inhibitors Targeting BTK C481S Mutation. ACS Med. Chem. Lett. 2025.