AMX5160
AMX5160 (36) is an orally active BTK inhibitor, with an IC50 of 0.98 nM against mutant BTKC481S. AMX5160 (36) can be used in the research for leukemia, lymphoma, multiple sclerosis, and other autoimmune diseases[1].
Product Specifications
CAS Number
2639293-95-9
UNSPSC
12352005
Target
Btk
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
ClC1=CC(OC2=CC=CC=C2)=CC=C1C(C3=CNC4=NC=CC(N[C@H](CC5)CC[C@H]5NC(C)=O)=C34)=O
Molecular Formula
C28H27ClN4O3
Molecular Weight
502.99
References & Citations
[1]Debasis Das, et al. Discovery of Reversible, Noncovalent Bruton’s Tyrosine Kinase Inhibitors Targeting BTK C481S Mutation. ACS Med. Chem. Lett. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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