MRL828

MRL828 combines a Tau pathology-binding ligand and modified guanine moiety based on the ATTEC technology to selectively designate aggregated tau proteins for clearance via the ALP. MRL828 decreases intracellular Tau aggregates and promotes the secretion of Tau[1].

Product Specifications

UNSPSC

12352005

Target

ATTECs; Autophagy; Tau Protein

Related Pathways

Autophagy; Neuronal Signaling; PROTAC

Field of Research

Neurological Disease

Smiles

O=C(NCCCOCCCCOCCCNC1=NC=C(C#CC2=CC=C(C3=CN4C=C(CO)C=CC4=N3)N=C2)C=N1)[C@@H](NC(C)=O)CSC5=NC6=C(N)N=C(N)N=C6N5CC7=CC=C(F)C=C7

Molecular Formula

C46H51FN14O5S

Molecular Weight

931.05

References & Citations

[1]Yekaterina Kovalyova, et al. Promoting Secretion of Pathological Tau Species Using an Induced Proximity Platform That Engages the Autophagy Pathway. ACS Chem Neurosci. 2025 May 9.