MRL828
MRL828 combines a Tau pathology-binding ligand and modified guanine moiety based on the ATTEC technology to selectively designate aggregated tau proteins for clearance via the ALP. MRL828 decreases intracellular Tau aggregates and promotes the secretion of Tau[1].
Product Specifications
UNSPSC
12352005
Target
ATTECs; Autophagy; Tau Protein
Related Pathways
Autophagy; Neuronal Signaling; PROTAC
Field of Research
Neurological Disease
Smiles
O=C(NCCCOCCCCOCCCNC1=NC=C(C#CC2=CC=C(C3=CN4C=C(CO)C=CC4=N3)N=C2)C=N1)[C@@H](NC(C)=O)CSC5=NC6=C(N)N=C(N)N=C6N5CC7=CC=C(F)C=C7
Molecular Formula
C46H51FN14O5S
Molecular Weight
931.05
References & Citations
[1]Yekaterina Kovalyova, et al. Promoting Secretion of Pathological Tau Species Using an Induced Proximity Platform That Engages the Autophagy Pathway. ACS Chem Neurosci. 2025 May 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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