BWA-6047

BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC degrader (AR: DC50 = 3.7 nM; AR-V7: DC50 = 3.0 nM; GSPT1: DC50 = 1.2 nM) . BWA-6047 promotes ubiquitination and degradation of AR/AR-V7 and, through its molecular glue properties, induces the formation of a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 can be used in prostate cancer research (Pink: AR/AR-V7 ligand (HY-176129) ; Blue: E3 CRBN ligand (HY-W069604) ; Black: linker (HY-W069604) ) [1].

Product Specifications

UNSPSC

12352005

Target

Androgen Receptor; Molecular Glues; PROTACs

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

O=C(CCCCCNC1=CC=C2C(N(C3C(NC(CC3)=O)=O)C(C2=C1)=O)=O)N4CCC(CC4)COC5=C(C#N)C=C(C(C)(C6=CC=C(C=C6)OC)C)C=C5Cl

Molecular Formula

C42H46ClN5O7

Molecular Weight

768.30

References & Citations

[1]Zhang B, et al. Rational Design of Dual Degraders by Incorporating Molecular Glue Structural Features into PROTAC Degraders. J Med Chem. 2025 May 9.