Adenosine-5'-O-diphosphoribose phosphate (sodium)

Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analog of NADPH (HY-113324) . Adenosine-5'-O-diphosphoribose phosphate sodium is an HMG-CoA reductase inhibitor. Adenosine-5'-O-diphosphoribose phosphate sodium inhibits microsomal HMG-CoA reductase with an apparent Ki value of 550 μM at low thiol concentrations[1].

Product Specifications

Product Name Alternative

ADP-ribose phosphate (sodium) ; P-ADP-Rib (sodium)

UNSPSC

12352005

Target

HMG-CoA Reductase (HMGCR)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

O[C@H]1[C@@H](OP(O[Na])(O[Na])=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@H]([C@H]([C@H](C=O)O)O)O)(O[Na])=O)(O[Na])=O

Molecular Formula

C15H20N5Na4O17P3

Molecular Weight

727.22

References & Citations

[1]Roitelman J, et al. Allosteric and non-allosteric forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase: differential inhibition of activity by adenosine 2'-monophospho-5'-diphosphoribose. J Lipid Res. 1986 Aug;27 (8) :828-35.