RJG-2051
RJG-2051 is a selective covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 value of 13 nM. RJG-2051 interferes with the metabolic process of substrates such as androgens, estrogens, and prostaglandins by AKR1C3. RJG-2051 is promising for research of cancers[1].
Product Specifications
CAS Number
[2851993-77-4]
UNSPSC
12352005
Target
Aldose Reductase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=CC=CC=C1N2CCN(CC2)C(C3=CC=C(C=C3)S(=O)(N4C=NC(C5CCCCC5)=N4)=O)=O
Molecular Formula
C26H31N5O4S
Molecular Weight
509.62
References & Citations
[1]Grams RJ, et al. Discovery and Optimization of a Covalent AKR1C3 Inhibitor. J Med Chem. 2025 Apr 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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