ASTX295
ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of [1].
Product Specifications
CAS Number
2093449-12-6
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Purity
99.81
Solubility
DMSO : 41.18 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CO[C@](C(C(C1=O)=C2)=C(F)C=C2[C@@](CC)(O)C3CCOCC3)(N1[C@H](C4=CC=C(Cl)C=C4)[C@H](C)C(O)=O)C5=CC=C(Cl)C=C5
Molecular Formula
C33H34Cl2FNO6
Molecular Weight
630.53
References & Citations
[1]Iqbal N, et al. ASTX295 a Novel Potent MDM2 Antagonist Induces More Than One Mechanism of Programmed Cell Death (PCD) in Lymphoid Malignancies[J]. Blood, 2024, 144: 3591.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
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