TEC 4
TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad ; Blue: Rpn-13 ligand (HY-159808) ; Black: linker (HY-W008352).
Product Specifications
UNSPSC
12352005
Target
ByeTAC; Epigenetic Reader Domain
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
BrC1=CC=C(CC2=NN=C(N2N=C3C4=CC=C(C=C4)Cl)SC3CC(NCCOCCOCCOCCOCCNC(C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C)=O)=O)C=C1
Molecular Formula
C48H51BrCl2N10O6S2
Molecular Weight
1078.92
References & Citations
[1]Loy CA, et al. ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation. J Med Chem. 2025 May 8;68 (9) :9694-9705.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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