HRG038
HRG038 is a selective covalent BRD4 degrader. HRG038 binds covalently to the E3 ubiquitin ligase CUL4 DCAF16, recruiting it to BRD4, leading to the ubiquitination and subsequent proteasomal degradation of BRD4. HRG038 is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
CC(N1C(S2)=C(C(C3=CC=C(Cl)C=C3)=N4)C(C)=C2C)=NN=C1[C@@H]4CC(N(CC5)CCN5C(/C=C/C(NC(C=N6)=CC(Cl)=C6N7N=CC=N7)=O)=O)=O
Molecular Formula
C34H31Cl2N11O3S
Molecular Weight
744.65
References & Citations
[1]Lauren M Orr, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. Biorxiv, April 25, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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