LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its truncated variant AR-V7. LO-4-25 covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, promoting the ubiquitination of AR and AR-V7, which subsequently are recognized and degraded by the proteasome, reducing the protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research of androgen-independent prostate cancers[1].
Product Specifications
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=CC(Cl)=CN=C1)/C=C/C(N2CCN(CC2)C(CCCCCOC3=CC=C(C=C3)C4=CSC(N5CCOCC5)=N4)=O)=O
Molecular Formula
C32H37ClN6O5S
Molecular Weight
653.19
References & Citations
[1]Lauren M Orr, et al. DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders. bioRxiv [Preprint]. April 25, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
USP28 Recombinant Antibody, AbBy Fluor™ 488 Conjugated
USP28 Recombinant Antibody, AbBy Fluor™ 488 Conjugated
2,4-Difluoro-5-methyl-α- (1-methylethyl) benzenemethanol
2,4-Difluoro-5-methyl-α- (1-methylethyl) benzenemethanol