Nav1.2-IN-1
Nav1.2-IN-1 (compound 5i), a 3- (1,2,3,6-tetrahydropyridine) -4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC50 value of 7.79 μM. Nav1.2-IN-1 exhibits antiepileptic activity. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ) -induced epilepsy mode[1].
Product Specifications
CAS Number
[3084825-09-9]
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC(C1=CC=C(C=C1)CN2CC=C(C3=CNC4=CC=CN=C43)CC2)(F)F
Molecular Formula
C20H18F3N3
Molecular Weight
357.37
References & Citations
[1]Bin Lou, et al. Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity. Eur J Med Chem. 2025 Aug 5:292:117664.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.2
Curated Selection
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