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HDAC6-IN-58

HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM and 7374.5 nM for HDAC6 and HDAC1, respectively. HDAC6-IN-58 increases tubulin acetylation, exerts antiproliferative effects, and induces autophagy[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; HDAC

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC(F)=C(C(F)=C1)CN2CN(C3(C2=O)CCN(CC4=CC=CC=C4)CC3)C5=CC=CC=C5)NO

Molecular Formula

C28H28F2N4O3

Molecular Weight

506.54

References & Citations

[1]Barone S, et al. Challenging triple negative breast cancer through HDAC6 selective inhibition: Novel cap-group identification, structure-activity relationships, computational and biological studies. Eur J Med Chem. 2025 Apr 18;292:117634.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC6

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