TRPV1 antagonist 11
TRPV1 antagonist 11 (compound 2ac) is a potent TRPV1 antagonist with an IC50 of 29.3 nM. TRPV1 antagonist 11 is a potent μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. TRPV1 antagonist 11, a pyrimidine piperazine, exhibits pain relieving effects by antagonizing TRPV1 and stimulating MOR. TRPV1 antagonist 11 shows a potent, dose-dependent anti-nociceptive effect in a Formalin-induced pain model in mice[1].
Product Specifications
CAS Number
[3084843-71-7]
UNSPSC
12352005
Target
Opioid Receptor; TRP Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=CC2=C(C(CCNC(N3CCN(CC3)C4=NC=CC(N5CCC(CC5)C6=CC=CC=C6)=N4)=O)=CN2)C=C1
Molecular Formula
C31H37N7O2
Molecular Weight
539.67
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV1; μ Opioid Receptor/MOR
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