Bictegravir-d7

Bictegravir-d7 (GS-9883-d7) is deuterium labeled Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.

Product Specifications

CAS Number

[2171092-56-9]

Product Name Alternative

GS-9883-d7

UNSPSC

12352005

Target

HIV; HIV Integrase; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C1N2[C@@](O[C@@]3([2H])C[C@]2([2H])CC3)([2H])C([2H])([2H])N4C1=C(C(C(C(NC([2H])([2H])C5=C(C=C(C=C5F)F)F)=O)=C4)=O)O

Molecular Formula

C21H11D7F3N3O5

Molecular Weight

456.42

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60 (12) :7086-7097.