HDAC6-IN-57

HDAC6-IN-57 (compound 9c) is an HDAC6 inhibitor with an IC50 value of 7 nM. HDAC6-IN-57 inhibits 60 cancer cell lines with a mean GI50 of 2.64 μM while exhibiting significantly lower cytotoxicity towards non-tumor cell lines[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NO)CCCCCCN1CC(N2[C@H](C1=O)CC3=C([C@@H]2C4=CC=CC(Br)=C4)NC5=CC=CC=C53)=O

Molecular Formula

C27H29BrN4O4

Molecular Weight

553.45

References & Citations

[1]Aya Fathy, et al. Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer. RSC Med Chem. 2025 Apr 17.