Hedgehog IN-9
Hedgehog IN-9 (Compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents GLI1 expression and enhances cellular BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid cells and can be used for synthesis of photoaffinity labeling probe[1].
Product Specifications
CAS Number
[438488-95-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Gli; Hedgehog
Related Pathways
Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCN1C(C2=C3C(C(S(=O)(NC4CCCCC4)=O)=CC=C31)=CC=C2)=O
Molecular Formula
C19H22N2O3S
Molecular Weight
358.45
References & Citations
[1]Tsakoumagkos IA, et al. Evaluation of Benzo[cd]indol-2 (1H) -ones as Downstream Hedgehog Pathway Inhibitors. ChemistryOpen. 2025 Apr 14:e202500119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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