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Hedgehog IN-9

Hedgehog IN-9 (Compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents GLI1 expression and enhances cellular BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid cells and can be used for synthesis of photoaffinity labeling probe[1].

Product Specifications

CAS Number

438488-95-0

UNSPSC

12352005

Target

Epigenetic Reader Domain; Gli; Hedgehog

Related Pathways

Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCN1C(C2=C3C(C(S(=O)(NC4CCCCC4)=O)=CC=C31)=CC=C2)=O

Molecular Formula

C19H22N2O3S

Molecular Weight

358.45

References & Citations

[1]Tsakoumagkos IA, et al. Evaluation of Benzo[cd]indol-2 (1H) -ones as Downstream Hedgehog Pathway Inhibitors. ChemistryOpen. 2025 Apr 14:e202500119.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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