PPO-allene
PPO-allene is a covalent botulinum neurotoxin (BoNT) light chain inhibitor (IC50: 20.9 μM) . PPO-allene (0.3 mg/kg, i.v.) demonstrates an in vivo half-life of approximately 1.5 h in mice[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Neurological Disease
Smiles
O=C1C=C(N=C2C(O)=C(C=CN21)CCCNC(C=C=C)=O)CNCC3=CC=C(C=C3)C4=CC=CC=C4
Molecular Formula
C29H28N4O3
Molecular Weight
480.56
References & Citations
[1]Lin M, et al. Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site. J Med Chem. 2025 Apr 24;68 (8) :8796-8816.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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